Born 24 April 1875 the fourth child and third son of Alfred Charles Mayo, MRCS 1870, of Mildenhall, Suffolk, and afterwards of Great Yarmouth, and Eleanor Matthews his wife. He was educated at Epsom College, and at Clare College, Cambridge, where he was a senior scholar in 1893 and took first-class honours in the Natural Sciences Tripos, part 1, 1896. He took his clinical training at St Bartholomew's Hospital, qualifying in 1898 and serving as house surgeon and extern midwifery assistant. Mayo spent his life in practice at Cowes, Isle of Wight. He was at first in partnership with William Hoffmeister, MRCS 1865, who had been surgeon to HM Queen Victoria in the Isle of Wight, and with H E W Hoffmeister, MRCS 1893. He lived successively at 9 The Parade, at Clifton House, and at Little Orchard, Cowes, where he died after a long illness on 1 November 1950, aged 75. He was local consulting surgeon to King Edward VII's Convalescent Home for Officers at Osborne, and to the Frank James Cottage Hospital, Cowes. For some years he was medical officer of health and police surgeon for Cowes. During the war of 1914-18 he served in the RAMC at Malta, and in and after the war of 1939-45 was chairman of the Isle of Wight medical war committee. He was chairman of the Isle of Wight division of the British Medical Association in 1938-39. Mayo married in 1902 Mildred, youngest daughter of Sir Thomas Smith, Bart, surgeon to St Bartholomew's Hospital. Mrs Mayo survived him, with their daughter and three grand-daughters; her brother Gilbert Smith, FRCS, had died earlier in 1950.