Born at Arklow, Ireland, on March 27th, 1822, was gazetted Assistant Surgeon to the 77th Foot on May 22nd, 1846, joined the Staff on August 18th, 1848, and the 67th Foot on March 18th, 1853. He was promoted Staff Surgeon (2nd Class) on December 8th, 1854, joined the 34th Foot on December 31st, 1858, rose to Surgeon Major on May 22nd, 1866, and was transferred to the Staff on April 7th, 1870. He was gazetted Deputy Surgeon General on February 28th, 1876, and Surgeon General on May 21st, 1881. He retired on May 27th, 1882. Manifold was one of the first to advocate women nurses for the Army, and obtained permission for their employment during a severe epidemic of small-pox among the garrison in Ireland in 1847, the great famine year. During the Crimean War he was in charge of the Officers' Hospital at Scutari, and Miss Florence Nightingale found in him a warm supporter of her nursing reforms. His unvarying kindness and unwearying attention made all the sick and wounded his friends. He served through the Indian Mutiny with the 34th Regiment, and was present at the defeat of the rebels near Bootwal on the Nepal Frontier on March 28th, 1859, for which he received the Medal. He died in retirement at Putney on January 6th, 1897. His son became Major-General Sir C C Manifold, KCB, IMS, the Chinese traveller.