After qualifying MB BS in Sydney in 1957 Francis Khin-Yoong became resident medical officer at the Royal North Shore Hospital in Sydney from 1957 to 1958; resident pathologist in 1959; demonstrator and lecturer in anatomy at the University of Sydney from 1959 to 1960 and surgical registrar at St Vincent's Hospital from 1961 to 1962. He specialised in obstetrics and was appointed resident obstetric medical officer to St Margaret's Hospital for Women in Sydney in 1963 and held the post of their deputy medical superintendant from 1964 to 1970. He came to England to study for the Fellowship of the College and worked at the King George Hospital in Ilford in 1965 and at the London Hospital the following year. He became a Fellow in 1966. Returning to Australia he worked as honorary clinical assistant to the Royal North Shore Hospital from 1966 to 1969 and St Vincent's Hospital from 1967 to 1970. He was honorary assistant gynaecologist at St Margaret's Hospital for Women from 1970 to 1980 and honorary consultant in gynaecology and obstetrics to the Mater Hospital from 1967. He died on 2 February 1989.