Born on 11 February 1882 one of the four sons of Sir George Watson Macalpine Kt (1850-1920) of Accrington, a colliery owner, brick manufacturer and President of the Baptist Union, and of his wife Arianne, daughter of James Barlow JP of Accrington, he was educated at Mill Hill School and Manchester U

Born in 1884, son of Francis Charles Bryan MRCS of Littlehampton, Sussex. He was educated at Westminster School and St Mary's Hospital, and held house appointments there and at Great Ormond Street. He spent several years in research, was demonstrator of bacteriology at Oxford, worked in Almroth Wrig