Ian Middleton was born in Troon, Ayrshire, on 20 October 1922. His father, John, was a medical practitioner and his mother was Emily, née Middleton. He went to school at Hymer's College, Hull, and then went on to the University of Aberdeen, having obtained first place in the medical bursary competit

Alexander Falconer Grant was born on 1 February 1926 in Sydney, Australia. His father, Chesborough Grant, was a public servant and his mother, Henrietta, née Leary, a nursing sister. Both his brothers became surgeons and both were awarded the OBE. He attended North Sydney Boys' High School and Sydne